梅素欢，1993年出生，女，博士，讲师，江西农业大学校聘教授，硕士生导师。江西农业大学第“五类人才”引进至生物科学与工程学院从事教学和科研工作。近年来在Food Research International、Food Bioscience、Food Chemistry、Critical Reviews in Food Science and Nutrition、Food and Chemical Toxicology和Journal of Agricultural and Food Chemistry等高水平期刊发表科研论文十余篇，担任多个期刊的审稿人及Food & Medicine Homology期刊的青年编委。
研究方向：
主要研究领域为天然产物的研究，涉及食品营养学和细胞生物学。研究方向为：
1、农副产品中功能性成分的分离和活性评价。
2、代谢组学技术和肠道菌群分析技术研究天然活性成分对肠道健康的影响。
3、网络药理学、计算机毒理学和细胞生物学研究天然产物的安全性。
4、食品加工过程中化学和功能变化机制。
二、教育经历
2022.12 - 2023.12，不列颠哥伦比亚大学，联合培养博士研究生。导师：Dr. David D Kitts；
2019.09 - 2023.12，江苏大学，食品科学与工程，博士研究生。导师：陈秀敏 教授；
2017.09 - 2019.06，山东师范大学，食品工程，硕士研究生。导师：耿越 教授、王骏 研究员；
2013.09 - 2017.06，山东师范大学，食品科学与工程，本科。
三、工作经历
2024.03 - 至今，江西农业大学，讲师、校聘教授。
四、主讲课程
生物分离工程、生物工艺学、研讨课、学术论文撰写与交流等。
五、主持课题
1、江西省科技厅，脂肪组织免疫稳态在多酚自氧化调节上皮细胞屏障功能中的机理研究，2024至今，20万元，主持在研，项目批准号：20244BCE52044。
2、江西省教育厅，基于酚酸自氧化探究多酚互作对肠屏障功能的调控机制，2024至今，3万元，主持在研，项目批准号：GJJ2400314。
3、江西农业大学博士启动经费，2024.03 - 至今，30万元。
六、 代表性研究成果
(1). Mei, S., Cao, Q., Huang, G., Chen, D., Kitts, D. D., & Chen, X. (2026). Polyphenol-Rich Coffee Leaf Extract Alleviates High-Fat Diet-Induced Intestinal Barrier Dysfunction through Modulation of Barrier Integrity, Enterohepatic Axis, and Gut Microbiota. Journal of agricultural and food chemistry, 74(6), 5286-5303. https://doi.org/10.1021/acs.jafc.5c13455.
(2). Mei, S., Li, Z., Wang, Q., Ma, H., & Chen, X. (2026). Anticancer Capacities of Green-Synthesized Zinc Oxide Nanoparticles Loaded with Mangiferin: Mechanistic Insights into Membrane Damage, pH Change, Oxidative Stress, Apoptosis, and Nuclear Lysis in HepG2 and Caco-2 Cells. Applied organometallic chemistry, 40(2), e70498. https://doi.org/10.1002/aoc.70498.
(3). Mei, S., Kitts, D.D. and Chen, X., 2024. Coffee leaf polyphenol-rich extracts alleviated lipopolysaccharide-induced intestinal barrier dysfunction: Insights from a Caco-2/U937 co-culture model. Food Bioscience. 61, 104639. https://doi.org/10.1016/j.fbio.2024.104639.
(4). Mei, S. and Chen, X., 2023. Combination of HPLC–orbitrap-MS/MS and network pharmacology to identify the anti-inflammatory phytochemicals in the coffee leaf extracts. Food Frontiers. 4, 1395–1412. https://doi.org/10.1002/fft2.248.
(5). Mei, S., Ding, J., & Chen, X. 2023. Identification of differential volatile and non-volatile compounds in coffee leaves prepared from different tea processing steps using HS-SPME/GC-MS and HPLC-Orbitrap-MS/MS and investigation of the binding mechanism of key phytochemicals with olfactory and taste receptors using molecular docking. Food Research International, 112760. https://doi.org/10.1016/j.foodres.2023.112760.
(6). Mei, S., and Chen, X. 2022. Investigation into the anti-inflammatory mechanism of coffee leaf extract in LPS-induced Caco-2/U937 co-culture model through cytokines and NMR-based untargeted metabolomics analyses. Food Chemistry: 134592. https://doi.org/10.1016/j.foodchem.2022.134592.
(7). Mei, S., Perumal, M., Battino, M., Kitts, D. D., Xiao, J., Ma, H., and Chen, X. 2021. Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety. Critical Reviews in Food Science and Nutrition 63(18), 3046-3064. https://doi.org/10.1080/10408398.2021.1983767.
(8). Mei, S., Ma, H., and Chen, X.,2021, Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms. Food and Chemical Toxicology,149:111997. https://doi.org/10.1016/j.fct.2021.111997.
(9). Mei, S., Song, X., Wang, Y., Wang, J., Su, S., Zhu, J., and Geng, Y. 2019. Studies on Protection of Astaxanthin from Oxidative Damage Induced by H2O2 in RAW 264.7 Cells Based on 1H NMR Metabolomics. Journal of Agricultural and Food Chemistry, 67(49): 13568-13576. https://doi.org/10.1021/acs.jafc.9b04587.
